MutectorTM Reagents for Oncology
Epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR and its complex signaling pathways play a central role in the regulation of cell proliferation and death. EGFR and its signaling components are promising targets for effective therapy for various cancers. Somatic mutations of EGFR and its downstream pathway components have been shown in a number of different cancers including melanoma, colorectal cancer, non-small cell lung cancer, papillary thyroid cancer, and ovarian cancer.
For example, approximately 35% to 45% of metastatic colorectal cancer (mCRC) tumors may have a KRAS or BRAF mutation, which negatively affects anti-EGFR therapies. On the other hand, approximately 50% of melanoma tumors may have a BRAF mutation, which increases the sensitivity to BRAF and MEK inhibitors. Thus, the detection of mutations in EGFR and its downstream pathway components is greatly important to personalized medicine and proper oncology therapies. TrimGen has developed and validated MutectorTM reagents to detect clinically relevant mutations of BRAF, KRAS, NRAS, and PIK3CA gene.
Available Products
| Cat. No. | Product Name | Targeted Mutations | Size | Documents |
| EP12 | BRAF mutation detection kit | Real time PCR detection of BRAF V600E | 32 rxn | Manual |
| EP14 | MYD88 mutation detection kit | Real time PCR detection of MYD L265P | 32 rxn | Manual |
| GP02-EK | BRAF mutation detection kit | 5 BRAF mutations in codon V600 | 32 rxn | Manual |
| GP05-C3 | KRAS mutation detection kit | 12 KRAS mutations in codon 12 & 13 | 32 rxn | Manual, Product flyer |
| GP06 | KRAS mutation detection kit | 5 KRAS mutations in codon 61 | 32 rxn | Manual, Product flyer |
| GP08 | PIK3CA Mutation detection kit | 5 PIK3CA mutation in exon 6 & 9 | 32 rxn | Manual |
| GP18 | NRAS mutation detection kit | 12 NRAS mutations in codon 12 & 13 | 32 rxn | Manual, Product flyer |
| GP19 | NRAS mutation detection kit | 4 NRAS mutations in codon 61 | 32 rxn | Manual, Product flyer |
| Cor-A | MutectorTM Core Reagents A | Universal reagents for detection of point mutations | 32 rxn | Product Flyer |
MutectorTM Core Reagents C | Universal reagents for detection of deletion, insertion, and translocations | 32 rxn |
For research use only. Not for use in diagnostic procedures.