Oncology Mutation Analysis

MutectorTM Reagents for Oncology

Epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR and its complex signaling pathways play a central role in the regulation of cell proliferation and death. EGFR and its signaling components are promising targets for effective therapy for various cancers. Somatic mutations of EGFR and its downstream pathway components have been shown in a number of different cancers including melanoma, colorectal cancer, non-small cell lung cancer, papillary thyroid cancer, and ovarian cancer.

For example, approximately 35% to 45% of metastatic colorectal cancer (mCRC) tumors may have a KRAS or BRAF mutation, which negatively affects anti-EGFR therapies. On the other hand, approximately 50% of melanoma tumors may have a BRAF mutation, which increases the sensitivity to BRAF and MEK inhibitors. Thus, the detection of mutations in EGFR and its downstream pathway components is greatly important to personalized medicine and proper oncology therapies. TrimGen has developed and validated MutectorTM reagents to detect clinically relevant mutations of BRAF, KRAS, NRAS, and PIK3CA gene.

Available Products

Cat. No. Product NameTargeted Mutations SizeDocuments
EP12BRAF mutation detection kitReal time PCR detection of BRAF V600E32 rxnManual
EP14MYD88 mutation detection kitReal time PCR detection of MYD L265P32 rxnManual
GP02-EKBRAF mutation detection kitBRAF mutations in codon V60032 rxnManual
GP05-C3KRAS mutation detection kit 12 KRAS mutations in codon 12 & 13 32 rxnManualProduct flyer
GP06KRAS mutation detection kit KRAS mutations in codon 6132 rxnManualProduct flyer
GP08PIK3CA Mutation detection kitPIK3CA mutation in exon 6 & 932 rxnManual
GP18NRAS mutation detection kit12 NRAS mutations in codon 12 & 13 32 rxnManual, Product flyer
GP19NRAS mutation detection kit4 NRAS mutations in codon 6132 rxnManualProduct flyer
Cor-AMutectorTM Core Reagents AUniversal reagents for detection of point mutations32 rxnProduct Flyer


MutectorTM Core Reagents C

Universal reagents for detection of deletion, insertion, and translocations

32 rxn

Product Flyer

For research use only. Not for use in diagnostic procedures.