The myeloid differentiation primary response 88 gene (MYD88) encodes a cytosolic adapter protein, which acts as an essential signal transducer in the IL-1, IL-18 and Toll-like receptor signaling pathways and plays a central role in the innate and adaptive immune response. The MYD88 L265P mutation is a gain-of-function driver mutation that has been found in more than 90% of Waldenström macroglobulinemia (WM) / lymphoplasmacytic lymphoma (LPL) patients (1-3).
The MYD88 L256P mutation detection kit was developed based on our eQ-PCR platform, a proprietary technology that has high sensitivity and detects mutation(s) as low as 1% mutant allele frequency.
- A single tube test – simple procedure and clear results
- Detection of MYD88 L265P mutation
- Results in less than 1.5 hours
- Works on any real-time PCR instrument
Assay information
Assay Format One tube test.
Assay Platform Real time PCR machine
Assay Sensitivity Detects 1-2% MYD88 L265P mutation
Sample required 20-100 ng DNA
| Cat. No. | Product Name | Mutations Interrogated | Size | Documents |
| EP14 | eQ-PCR MYD88 Mutation Analysis | MYD88 L265P | 32 rxn | Manual |
For research use only. Not for use in diagnostic procedures.
Example results:
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References
- Landgren O & Tageja N (2014). MYD88 and beyond: novel opportunities for diagnosis, prognosis and treatment in Waldenström's Macroglobulinemia. Leukemia. 28:1799.
- Treon SP et al. (2012). MYD88 L265P somatic mutation in Waldenström’s macroglobulinemia. N Engl J Med. 367:826.
- Hamadeh F et al. (2015). MYD88 L265P mutation analysis helps define nodal lymphoplasmacytic lymphoma. Mod Pathol. 28:564.