Mutations in KRAS and NRAS genes are found in approximately a third of all human cancers. Clinical studies indicate that patients with tumors containing KRAS / NRAS mutations are unlikely to benefit from anti–EGFR therapy. Identifying KRAS / NRAS mutations helps determine the appropriate treatment for patients with cancer. Trimgen's RAS mutation panels identify all KRAS / NRAS mutations listed in ASCO, CAP, AMP and ASCP joint guidelines.
Assay Workflow | New joint guideline (Jan 2016) for KARS and NRAS tests - by CAP, AMP, ASCO, and ASCP "Patients with mCRC should have their tumor tested for mutations in: KRAS exons 3 (codons 59 and 61), KRAS exons 4(codons 117 and 146), NRAS exons 2 (codons 12 and 13), NRAS exons 3 (codons 59 and 61), and NRAS exons 4 (codons 117 and 146) in addition to the previously recommended testing of KRAS exon 2 (codons 12 and 13)".
STA technology uses special chemistry to enrich mutation signal for low level mutations detection. The STA assay has been widely used to detect BRAF, KRAS and other mutations see STA publications.
Features
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Order Information
Product Name | Target Mutations | Documents | |
KRAS Cat No. GP05-C3 32 reactions
| Codon 12: | G12S (AGT), G12R (CGT), G12C (TGT), G12D (GAT), |
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Codon 13: | G13S (AGC), G13R (CGC), G13C (TGC), G13D (GAC), G13A(GCC), G13V (GTC) |
Product Name | Target Mutations | Documents | |
KRAS Plus Cat No. GP06P 32 reactions
| Codon 61: | Q61H (CAT), Q61L (CTA), Q61R (CGA), Q61E (GAA), |
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Codon 117: | K117E (GAA), K117N (AAC), K117N (AAT) | ||
Codon 146: | A146T (ACA), A146P (CCA),A146G (GGA), A146V (GTA) |
Product Name | Target Mutations | Documents | |
NRAS Cat No. GP18 32 reactions
| Codon 12: | G12S (AGT), G12R (CGT), G12C (TGT), G12D (GAT), |
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Codon 13: | G13S (AGT), G13R (CGT), G13C (TGT), G13D (GAT), G13A(GCT), G13V (GTT) |
Product Name | Target Mutations | Documents | |
NRAS Plus Cat No. GP19P 32 reactions
| Codon 61: | Q61H (CAT), Q61L (CTA), Q61R (CGA), Q61E (GAA), |
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Codon 117: | K117A (GCG), K117N (AAC), K117N (AAT) | ||
Codon 146: | A146T (ACA), A146P (CCA), A146V (GTA) |
All product are for research use only. Not for use in diagnostic procedures. |
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