Pharmacogenetics Testing

The standard dose of a prescribed drug can cause a serious adverse response in one patient and less of a response in another. Genetic variability is directly linked to an individual's drug response. By analyzing the individual variations in the genes that produce enzymes involved in metabolizing drugs, a physician can provide a more effective treatment plan, avoiding adverse drug reaction, toxicity, or lack of drug efficacy.

Cytochrome P450 (CYP) enzymes account for 70-80% of enzymatic activity involved in drug metabolism. The genetic variations of CYP genes affect enzyme activity, which in turn affects drug metabolism. For example, CYP2D6, a member of the CYP oxidase system, was shown to be responsible for the metabolism and elimination of approximately 25% of clinically used drugs. The genetic variations (polymorphism) of the CYP2D6 genes affect its function in drug metabolisms. Thus, the identification of genetic variations of CYP and its downstream pathway components are greatly important to personalized medicine and proper treatment. Based on the ability to metabolize its substrates, an individual’s CYP2D6 function can be categorized as one of the following: poor metabolizer (PM), intermediate metabolizer (IM), extensive metabolizer (EM), and ultrarapid metabolizer (UM).


Clear-Cut Results          Target SNP shows as two peaks and individual SNP peak is discerned by different color & size. It is easy to analyze the allele
Multiplex Detection       Single tube tests multiple SNPs in different exons or genes
Flexibility                      Easy to add new SNPs without changing protocol

Assay Information

 Assay method                 Shifted Termination Assay (STA)

Sample required                20-100 ng DNA

Assay Time                      3 hours

Instrument required           PCR machine and capillary sequencer ABI 3100, 3700, 3130, 3500  

Order information

Cat. No. Product NameTargeted SNPs SizeDocuments
GP03Warfarin genotyping kitVKORC1 -1639G>A, CYP2C9 *2, *332 rxnTest info 
GP11CYP2D6 genotyping kitCYP2D6 *2, *3, *4, *5, *6, *9, *10, *17, *41, 4180G>C32 rxnTest info
GP12CYP2C19 genotyping kitCYP2C19 *2, *3, *4, *5, *6, *7, *8, *1732 rxnTest info

For research use only. Not for use in diagnostic procedures.